New Zealand Journal of Botany abstract
Biologically active compounds from Ozothamnus leptophyllus
JACQUELINE E. WOOD
MURRAY H. G. MUNRO
JOHN W. BLUNT
NIGEL B. PERRY*
Department of Chemistry
University of Canterbury
Private Bag 4800
Christchurch, New Zealand
* Present address: Plant Extracts Research Unit, Department of
Chemistry, University of Otago, P.O. Box 56, Dunedin, New Zealand.
JOHN R. L. WALKER+
JOSEPHINE M. WARD
Department of Plant and Microbial Sciences
University of Canterbury
Private Bag 4800
Christchurch, New Zealand
Abstract A crude extract from a New Zealand native plant,
Ozothamnus leptophyllus, was shown to possess
antifungal
activity. Flavonoids, mainly chalcones in the leaf exudate, were isolated, some
of which possessed antiviral as well as antifungal activity. These flavanoids
are excreted by glandular trichomes and form quasi-crystalline deposits on the
abaxial side of the leaves.
2[[minute]],4[[minute]],6[[minute]]-Trihydroxychalcone was found to be active
against both
Polio virus (Pfizer vaccine strain) and
Herpes
simplex type 1 (ATCC VR 733); it was also responsible for
anti-dermatophytic activity against
Trichophyton mentagrophytes.
2[[minute]],4[[minute]]-Dihydroxy-4[[minute]]-methoxy-dihydrochalcone was also
active against both viruses.
Keywords Ozothamus leptophyllus; Compositae;
antiviral; antifungal; chalcones; leaf exudate; flavonoids
+Author for correspondence
B97086
Received 10
December 1997; accepted 4 August 1998
PDF file of entire paper: medium quality (1110K); (scanned from paper original: notes about this process)
This year's abstracts |Journal home page |All abstracts | Publishing home page
