New Zealand Journal of Zoology abstracts
Acute oral toxicity of p-aminopropiophenone to stoats (Mustela
erminea)
Penny M. Fisher
Cheryl E. O’Connor
Landcare Research
P.O. Box 69
Lincoln 8152, New Zealand
Elaine C. Murphy
Department of Conservation
Private Bag 4715
Christchurch, New Zealand
Abstract No toxic baits are currently registered
in New Zealand for stoat (Mustela erminea) control. PAPP (p-aminopropiophenone)
has potential application as a vertebrate pesticide for stoat control
in New Zealand, and in the hydrochloride form was highly toxic (LD50 9.3 mg/kg)
to stoats in pen trials. The first visible signs of toxicosis, cyanosis
and salivation, generally appeared within 20 min of gavage
administration of PAPP. These signs were generally followed by
rapid respiration, lack of co-ordination and lethargy. Death generally
followed within an hour of receiving a lethal dose. Stoats remained at
least partly conscious until just prior to death, or may have had
periods of intermittent consciousness in the later stages. PAPP
toxicosis in stoats appeared relatively rapid (in comparison with other
vertebrate pesticides in mustelids) and on preliminary assessment
appears relatively humane. Further investigation and development of
targeted bait delivery of PAPP for stoat control in New Zealand is
recommended. This should be conducted alongside formal assessment of
humaneness and the potential for unwanted effects such as non-target
mortality and environmental contamination.
Keywords control; lethal dose; poisoning;
p-aminopropiophenone; p-aminopropiophenone hydrochloride; stoat; time
to death; vertebrate pesticide
Z05003; Received 2 February 2005; accepted 28 April 2005; Online
publication date 4 August 2005
New Zealand Journal of Zoology, 2005, Vol. 32: 163–169
0301–4223/05/3203–0163 © The Royal Society of New Zealand 2005
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